“Personalizing healthcare through precision medicine”
Dr Mitsides is an Academic Physician in Nephrology and General Internal. He graduated from the University of Manchester in 2004 and has practiced medicine in the United Kingdom for 17 years. He has held the NIHR Devices for Dignity Nephrology Innovation Research Fellowship providing clinical support and input to the National Institute for Healthcare Research Devices for Dignity MedTech Co-operative. During this time, he worked with academic institutions and SMEs to guide 13 projects funded through the first Small Business Research Initiative competition in the UK dedicated to renal disease and was organised by the UK Ministry of Health. He was awarded his PhD by the University of Manchester for his research work in salt and fluid overload in advanced Chronic Kidney Disease and haemodialysis in 2019. He has presented his work at a number of international conferences and has published articles and book chapters in his area of clinical and academic interest. He is a Member of the Royal College of Physicians of UK and has completed his Speciality Certificate Examination in Nephrology in 2012. He has worked as a Consultant Nephrologist first at Salford Royal Hospital NHS Foundation Trust and then at University Hospitals of Derby and Burton NHS Foundation Trust. Since 09/2023 Dr Mitsides is the President of the Cyprus Renal Association.
He has also an interest in the design and delivery of undergraduate and postgraduate clinical teaching. He holds a Postgraduate Diploma in Clinical Education awarded with Distinction by Edge Hill University in 2018. He is currently the postgraduate speciality training program coordinator for nephrology in the district of Nicosia and a faculty member of the MSc program of the University of Cyprus’ Medical School in Precision Medicine in Clinical Practice.
Dr Nicos Mitsides
MBChB, MRCP UK (Neph), PGDip MedEd (Dist), PhD
Lecturer and Consultant Nephrologist/General Physician; Medical School, University of Cyprus & Nephrology Department, Nicosia General Hospital
This email address is being protected from spambots. You need JavaScript enabled to view it.; (+357) 22 895245
Investigating Steady State and Dynamic Fluid Distribution in
Advanced Chronic Kidney Disease and during ultrafiltration in Haemodialysis
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The study of compartmental sodium distribution in patients with advanced CKD using a magnetic resonance imaging technique (SoDiUM).
This study aimed to look into the compartmental sodium distribution in the diseased state of advanced chronic kidney disease and whether this deviates from the normal steady state. To study this a novel approach was used using Sodium MRI imaging. Also, associations between vascular endothelial and inflammatory biomarker with increased tissue salt deposition were investigated. As part of the study the influence of water-free sodium tissue accumulation on measurements of bioelectrical impedance and its ability to accurately assess fluid overload in CKD was also studied. This work is a collaboration between Manchester University NHS Foundation Trust, the Centre of Imaging Science of the University of Manchester and the Healthcare Sciences Research Institute of Manchester Metropolitan University. The initial findings of the project have been reported.
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Kidney Injury
Biomarkers in
Clinical Practice
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‘A performance evaluation study of a point of care device for measurement of urinary L-FABP in the diagnosis and monitoring of kidney disease’ (ELUDE).
This is an industry-funded study by CIMIC Co Ltd (Tokyo, Japan) performed in collaboration with Manchester University NHS Foundation. The study had 4 components:
- Assessment of urinary Liver type Fatty Acid Binding Protein (L-FABP), a promising biomarker of acute kidney injury in unselected acute hospital admissions. Analysis is still on-going.
- Assessment of the potential use of urinary L-FABP as a biomarker of acute kidney injury in a high-risk group of patients undergoing Haemopoetic Stem Cell Transplantation. This component is currently reporting its findings.
- Assessment of the potential use of Urinary L-FABP as a biomarker of chronic kidney disease progression. This part of the study recently published its findings showing that L-FABP could have an important role in assessing chronic kidney disease.
- Evaluation of the performance of semiquantitative point of care device for detecting urinary L-FABP against the commercially available ELISA.
- ‘An investigation of transcapillary plasma refill during ultrafiltration in haemodialysis’ (PRUF).
This study aims to look into the dynamic fluid movements across different body compartments during fluid removal (ultrafiltration) during haemodialysis treatment. This study utilized a novel dilution technique approach and the haemodialysis machine’s ultrasonic blood volume monitoring module in conjunction with the machine's software. This study is being performed in collaboration with Manchester University NHS Foundation Trust and the Institute of Biocybernetics and Biomedical Engineering in Warsaw. Initial findings have been reported while analysis of the biomathematical models of transcapillary refill is ongoing.
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Improving the Lifes of patients with
Advance Chronic Kidney Disease through Novel Interventions
This study aims to describe practices and perceptions of healthcare professionals concerning the treatment pathway dealing with patients in advanced chronic kidney disease (CKD) and the patient experiences going through the transition from advanced CKD to Renal Replacement Therapy (RRT) dependence with emphasis on their anxiety, depression and emotional distress. We hope to gain understanding of the influence of patients’ demographic background and emotional state on the decision-making and cognitive need of patients to personalise their management.
- The effects of long-term hybrid intradialytic exercise on cognitive function and quality of life in patients with chronic kidney disease: a randomised controlled trial
This a collaborative project with the Research Centre for Exercise and Nutrition (RECEN) of the University of Nicosia and the Nephrology Department of Nicosia General Hospital. It aims through a cross-sectional analysis and a randomised controlled study to evaluate the impact of exercise during haemodialysis sessions on cognitive function, body composition and quality of life as well as other patient reported outcomes.
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